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. 2016 Jun 23;6:28299. doi: 10.1038/srep28299

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(A) qPCR confirmed that expression of CD44, a putative cancer stem cell (CSC) marker, was almost completely eliminated in TCF7L1-Null cells. Another CSC marker, EPCAM, had a modest reduction in TCF7L1-Null cells. (B) Flow cytometry with an APC-conjugated CD44 antibody revealed that TCF7L1-Null cells had significantly fewer CD44 + cells than control cells. (P < 0.01 for both clones, average was taken across three experiments.) FITC-conjugated EPCAM followed a similar trend, but with a less dramatic reduction in expression (P < 0.05 for both clones, average was taken across three experiments).