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. 2016 Jun 23;6:28283. doi: 10.1038/srep28283

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Schema of experiment protocol. Neonatal liver were minced and purified with CD133 antibodies, and directly seeded into 3D extracellular matrix gels. After 7 days of culture, they formed many cysts. (b) Confocal microscopic images of cysts derived from neonatal CD133⁺ liver cells. (i) Cysts derived from neonatal CD133⁺ cells expressed cholangiocytic marker CK19 but not hepatocytic marker ALBUMIN. (c) The cysts had epithelial polarity that β-CATENIN (green) located basolateral region and aPKC (red) located luminal region. Scale bars, 100 μm. (d) Schema of foetal LPC differentiation into cholangiocytic progenitor cells in vitro and in vivo. Illustrations were permitted for publication.