Table 2. Comparison of frequency distributions of WNT pathway polymorphisms in Chinese Han population.
| Gene | SNP | Group | Allele n (%) |
OR (95% CI) | P* | P** | Genotype n (%) |
P* | P** | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 11 | 12 | 22 | ||||||||
| CTNNB1 | rs9859392 | TB | 316 (19.41) | 1312 (80.59) | 0.75 (0.64–0.88) | 4.07 ×10−4 | 0.009 | 38 (4.67) | 240 (29.48) | 536 (65.85) | 6.57 × 10−4 | 0.013 |
| C > G | HC | 515 (24.25) | 1609 (75.75) | 60 (5.65) | 395 (37.19) | 607 (57.16) | ||||||
| rs9870255 | TB | 323 (19.84) | 1305 (80.16) | 0.76 (0.65–0.89) | 7.66 × 10−4 | 0.018 | 34 (4.18) | 255 (31.32) | 525 (64.50) | 0.003 | 0.092 | |
| G > C | HC | 522 (24.46) | 1612 (75.54) | 64 (6.00) | 394 (36.92) | 609 (57.08) | ||||||
| rs3864004 | TB | 322 (19.80) | 1304 (80.20) | 0.77 (0.66–0.91) | 0.001 | 0.033 | 36 (4.43) | 250 (30.75) | 527 (64.82) | 0.007 | 0.149 | |
| G > A | HC | 509 (24.19) | 1595 (75.81) | 67 (6.37) | 375 (35.65) | 610 (57.98) | ||||||
| WIF1 | rs34203757 | TB | 280 (17.11) | 1356 (82.89) | 0.92 (0.78–1.09) | 0.327 | 28 (3.47) | 224 (27.72) | 556 (68.81) | 0.592 | ||
| C > G | HC | 385 (18.14) | 1737 (81.86) | 44 (4.19) | 297 (28.31) | 708 (67.49) | ||||||
| rs34505206 | TB | 270 (16.52) | 1364 (83.48) | 0.87 (0.74–1.03) | 0.116 | 29 (3.55) | 212 (25.95) | 576 (70.50) | 0.311 | |||
| C > G | HC | 390 (18.50) | 1718 (81.50) | 46 (4.36) | 298 (28.27) | 710 (67.37) | ||||||
| rs56900803 | TB | 200 (12.27) | 1430 (87.73) | 1.00 (0.82–1.22) | 0.987 | 15 (1.84) | 170 (20.86) | 630 (77.30) | 0.359 | |||
| G > T | HC | 260 (12.25) | 1862 (87.75) | 12 (1.13) | 236 (22.24) | 813 (76.63) | ||||||
| DKK1 | rs11001553 | TB | 119 (7.48) | 1471 (92.52) | 1.04 (0.81–1.34) | 0.737 | 7 (0.88) | 105 (13.21) | 683 (85.91) | 0.925 | ||
| C > T | HC | 156 (7.2) | 2012 (92.80) | 8 (0.73) | 140 (12.92) | 936 (86.35) | ||||||
| rs1896367 | TB | 494 (30.31) | 1136 (69.69) | 0.98 (0.85–1.13) | 0.792 | 72 (8.83) | 350 (42.94) | 393 (48.23) | 0.272 | |||
| G > A | HC | 662 (30.71) | 1494 (69.29) | 115 (10.67) | 432 (40.07) | 531 (49.26) | ||||||
| rs1896368 | TB | 623 (38.46) | 997 (61.54) | 0.96 (0.84–1.09) | 0.499 | 114 (14.07) | 395 (48.77) | 301 (37.16) | 0.131 | |||
| G > A | HC | 825 (39.55) | 1261 (60.45) | 178 (17.06) | 469 (44.97) | 396 (37.97) | ||||||
| SFRP1 | rs3242 | TB | 101 (6.17) | 1535 (93.83) | 0.96 (0.74–1.25) | 0.776 | 13 (1.59) | 75 (9.17) | 730 (89.24) | 0.788 | ||
| C > T | HC | 138 (6.4) | 2018 (93.60) | 7 (0.65) | 124 (11.50) | 947 (87.85) | ||||||
| rs4736958 | TB | 471 (28.79) | 1165 (71.21) | 0.78 (0.69–0.92) | 0.001 | 0.033 | 79 (9.66) | 313 (38.26) | 426 (52.08) | 0.003 | 0.092 | |
| T > C | HC | 727 (33.66) | 1433 (66.34) | 125 (11.57) | 477 (44.17) | 478 (44.26) | ||||||
| rs72643819 | TB | 648 (39.80) | 980 (60.20) | 1.12 (0.98–1.28) | 0.088 | 154 (18.92) | 340 (41.77) | 320 (39.31) | 0.063 | |||
| G > T | HC | 798 (37.08) | 1354 (62.92) | 160 (14.87) | 478 (44.42) | 438 (40.71) | ||||||
| rs7832767 | TB | 483 (29.45) | 1157 (70.55) | 1.30 (1.11–1.48) | 6.93 × 10−4 | 0.016 | 89 (10.85) | 305 (37.20) | 426 (51.95) | 8.81 × 10−4 | 0.021 | |
| C > T | HC | 529 (24.54) | 1627 (75.46) | 68 (6.31) | 393 (36.46) | 617 (57.24) | ||||||
| WNT1 | rs4760662 | TB | 808 (49.88) | 812 (50.12) | 1.01 (0.88–1.15) | 0.924 | 210 (25.93) | 388 (47.90) | 212 (26.17) | 0.778 | ||
| C > T | HC | 1064 (49.72) | 1076 (50.28) | 267 (24.95) | 530 (49.53) | 273 (25.52) | ||||||
| rs4760663 | TB | 778 (47.67) | 854 (52.33) | 1.01 (0.89–1.14) | 0.922 | 204 (24.85) | 380 (46.28) | 237 (28.87) | 0.297 | |||
| C > T | HC | 1036 (47.83) | 1130 (52.17) | 248 (22.90) | 540 (49.86) | 295 (27.24) | ||||||
| WNT3A | rs13373831 | TB | 339 (20.60) | 1307 (79.40) | 0.94 (0.80–1.10) | 0.409 | 43 (5.22) | 253 (30.74) | 527 (64.04) | 0.423 | ||
| A > G | HC | 464 (21.70) | 1674 (78.30) | 42 (3.93) | 380 (35.55) | 647 (60.52) | ||||||
| rs708113 | TB | 590 (36.88) | 1010 (63.12) | 1.04 (0.91–1.19) | 0.607 | 118 (14.75) | 354 (44.25) | 328 (41.00) | 0.288 | |||
| T > A | HC | 760 (36.05) | 1348 (63.95) | 132 (12.52) | 496 (47.06) | 426 (40.42) | ||||||
| rs74672629 | TB | 164 (9.98) | 1480 (90.02) | 0.92 (0.74–1.14) | 0.440 | 7 (0.85) | 150 (18.25) | 665 (80.90) | 0.530 | |||
| C > G | HC | 226 (10.75) | 1876 (89.25) | 7 (0.67) | 212 (20.17) | 832 (79.16) | ||||||
| rs752107 | TB | 398 (24.54) | 1224 (75.46) | 0.86 (0.74–1.00) | 0.047 | > 0.999 | 45 (5.55) | 308 (37.98) | 458 (56.47) | 0.101 | ||
| C > T | HC | 590 (27.44) | 1560 (72.56) | 69 (6.42) | 452 (42.05) | 554 (51.53) | ||||||
| WNT5A | rs2076831 | TB | 597 (36.67) | 1031 (63.33) | 1.04 (0.91–1.19) | 0.605 | 112 (13.76) | 373 (45.82) | 329 (40.42) | 0.727 | ||
| C > G | HC | 768 (35.85) | 1374 (64.15) | 148 (13.82) | 472 (44.07) | 451 (42.11) | ||||||
| rs3732750 | TB | 189 (11.60) | 1441 (88.40) | 1.23 (1.00–1.51) | 0.055 | 9 (1.10) | 171 (20.98) | 635 (77.91) | 0.143 | |||
| G > A | HC | 208 (9.67) | 1944 (90.33) | 7 (0.65) | 194 (18.03) | 875 (81.32) | ||||||
| rs504849 | TB | 603 (36.90) | 1031 (63.10) | 1.00 (0.87–1.14) | 0.971 | 144 (17.00) | 375 (44.27) | 328 (38.73) | 0.999 | |||
| A > G | HC | 788 (36.96) | 1344 (63.04) | 149 (13.98) | 490 (45.97) | 427 (40.06) | ||||||
| rs566926 | TB | 612 (38.25) | 988 (61.75) | 1.01 (0.89–1.16) | 0.849 | 114 (14.25) | 384 (48.00) | 302 (37.75) | 0.268 | |||
| A > C | HC | 812 (37.94) | 1328 (62.06) | 169 (15.79) | 474 (44.30) | 427 (39.91) | ||||||
SNPs were bolded and underlined if they showed a significance of p < 0.05; “1” designates the mutant allele and “2” designates the wild allele; 11 = mutant homozygote, 12 = heterozygote, 22 = wild homozygote; OR = odds ratio, followed by 95% CI in parentheses. P*: p value after adjusting for age, gender and BMI; P**: p value after Bonferroni correction.