Table 4. Haplotype association of SNPs in WNT pathway and tuberculosis.
Gene | Haplotypea | Frequency |
OR (95% CI) | P | P** | ||
---|---|---|---|---|---|---|---|
All | TB | HC | |||||
CTNNB1 | CGG | 0.764 | 0.785 | 0.748 | 1.00 | ||
GCA | 0.212 | 0.175 | 0.240 | 0.69 (0.60–0.83) | 5.85 × 10−4 | 0.016 | |
WNT5A | AAC | 0.617 | 0.614 | 0.619 | 1.00 | ||
CGG | 0.359 | 0.366 | 0.354 | 1.03 (0.90–1.17) | 0.700 | ||
CAC | 0.014 | 0.019 | 0.010 | 2.04 (1.15–3.62) | 0.054 | ||
WNT1 | CC | 0.502 | 0.496 | 0.508 | 1.00 | ||
TT | 0.475 | 0.480 | 0.47 | 1.01 (0.89–1.15) | 0.840 | ||
CT | 0.023 | 0.024 | 0.022 | 1.13 (0.73–1.76) | 0.590 | ||
WIF1 | CC | 0.819 | 0.830 | 0.811 | 1.00 | ||
GG | 0.175 | 0.126 | 0.185 | 0.88 (0.74–1.03) | 0.120 |
P**: p value after Bonferroni correction.
aHaplotype frequency <0.01 in both cases and controls has been dropped; significant associations were denoted in bold. Wild haplotype was set as the reference, and the OR of other haplotypes were calculated.