Figure 3.

Representative rintatolimod blood elimination curves: (a) 200 mg (n = 6), (b) 400 mg (n = 12), and (c) 700 mg (n = 4) dose groups. Rintatolimod was delivered as a single bolus over an infusion period of 23–60 minutes. Rintatolimod and its metabolites (>50–100 nucleotides) were determined by hybridization employing a [³H]poly(C) probe. Each point is the average of duplicate concentration determinations at the designated dose and within 2.5 minutes of the time indicated. Each curve is the product of ‘n’ infusions, using first order decay kinetics. Revised from the doctoral thesis of Kenneth Strauss [25] with permission from the author.