Table 6.
Clinical characteristics and echocardiographic parameters of patients with chronic organic mitral regurgitation and the comparisons between subgroups of patients according to the symptom status and the severity of mitral regurgitation
| Variables | Total (N = 154) | Symptom status | Severity of MR | ||||
|---|---|---|---|---|---|---|---|
| Symptomatic (N = 58) | Asymptomatic (N = 96) | P-value | Severe MR (N = 123) | Non-severe MR (N = 31) | P-value | ||
| Symptomatic | 58 (37.7) | - | - | - | 46 (37.4) | 12 (38.7) | 1.0 |
| Severe MR | 123(79.9) | 46 (79.3) | 77 (80.2) | 1.0 | - | - | - |
| Age (years) | 55.0 ± 16.4 | 58.3 ± 16.2 | 53.0 ± 16.3 | 0.051 | 55.3 ± 16.1 | 53.9 ± 17.9 | 0.684 |
| Male gender | 93(60.4) | 30(51.7) | 63(65.6) | 0.087 | 82(66.7) | 11(35.5) | 0.002 |
| Atrial fibrillation | 45(29.4) | 25(43.1) | 20(21.1) | 0.004 | 34(27.9) | 11(35.5) | 0.406 |
| LVDd (mm) | 56.9 ± 6.6 | 57.7 ± 7.5 | 56.3 ± 5.9 | 0.245 | 58.3 ± 6.3 | 51.1 ± 4.1 | <0.001 |
| LVSd (mm) | 33.8 ± 5.7 | 34.5 ± 6.3 | 33.4 ± 5.3 | 0.238 | 34.5 ± 5.8 | 31.0 ± 4.4 | <0.001 |
| LVEDV (ml) | 113.3 ± 33.0 | 114.2 ± 36.4 | 112.8 ± 30.9 | 0.810 | 119.5 ± 32.3 | 89.0 ± 22.9 | <0.001 |
| LVESV (ml) | 36.5 ± 13.6 | 37.8 ± 15.5 | 35.7 ± 12.3 | 0.382 | 38.0 ± 13.8 | 30.4 ± 10.5 | 0.005 |
| LVMI (g/m2) | 146.4 ± 43.44 | 163.8 ± 50.7 | 135.5 ± 34.3 | <0.001 | 154.6 ± 42.5 | 113.3 ± 29.8 | <0.001 |
| E/E’ | 15.9 ± 6.1 | 18.0 ± 6.1 | 14.8 ± 5.9 | 0.002 | 16.6 ± 6.2 | 13.3 ± 5.0 | 0.008 |
| TAPSE (mm) | 22.7 ± 4.6 | 21.5 ± 4.6 | 23.4 ± 4.4 | 0.010 | 22.9 ± 4.5 | 22.0 ± 4.9 | 0.307 |
| EROA (mm2) | 61.8(22.0–250.9) | 78.7(23.0–250.9) | 56.5(22.0–225.1) | 0.080 | 72.0(40.0–250.9) | 28.9(22.0–44.9) | <0.001 |
| RVol (ml) | 102.1(20.3–336.2) | 114.8(36.2–336.2) | 95.5(20.3–267.9) | 0.058 | 113.3(61.3–336.2) | 48.1(20.3–75.0) | <0.001 |
| LAV index (ml/m2) | 67.1(24.7–391.3) | 80.4(30.3–391.3) | 62.5 (24.7–276.3) | 0.007 | 71.7(30.3–391.3) | 46.3(24.7–145.0) | <0.001 |
| RVSP (mmHg) | 43.2 ± 17.7 | 49.0 ± 18.0 | 39.6 ± 16.5 | 0.001 | 44.9 ± 18.7 | 36.3 ± 10.4 | 0.001 |
Data are expressed as number (percentage), median (min-max) or mean ± standard deviation
P-values are for comparisons between 2 groups
E peak early diastolic velocity of mitral inflow, E’ tissue Doppler peak early diastolic velocity of medial mitral annulus, EROA effective regurgitant orifice area, LAV left atrial volume, LVDd left ventricular end-diastolic diameter, LVSd left ventricular end-systolic diameter, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LVMI left ventricular mass index, MR mitral regurgitation, RVol regurgitant volume, RVSP right ventricular systolic pressure, TAPSE tricuspid annular plane systolic excursion