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. 2015 Nov 1;37:23. doi: 10.1186/s41021-015-0023-7

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Metabolic events upon arsenic consumption deplete the methylation pool within the cell. “**” indicates that AS3MT is a highly polymorphic enzyme. It’s polymorphic profile can determine the degree of biotransformation of inorganic arsenic within the cellular system. This may induce indirectly the epigenetic susceptibility as discussed in section Polymorphism and arsenic-induced epigenetic susceptibility