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Rejuvenation of HGPS cells by enforced expression of human telomerase gene (hTERT). a Envelope-surface ratio (ESR) of nuclei. b Expression level of progerin. c Number of 53BP1 foci per nucleus in HGPS cells (AG11513 cells at PDs ~23) and the hTERT-introduced cells (PDs ~110). d Number of unrepairable repair foci at 12-Gy/ 1-month. e Proposed model of telomerase mediated rejuvenation
