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. 2016 Jun 23;13:162. doi: 10.1186/s12974-016-0630-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Neutralizing CCL20 improves histopathological outcome in the injured spinal cord. a H&E staining of the spinal cord sections at 28 days post-SCI shows varying sizes of the cystic cavity, inflammatory cell infiltration, and formation of a glial scar around the cavity. Scale bar = 1 mm. b, c Quantitative data of lesion tissue and spared tissue shows a significantly decreased lesion volume and increased spared tissue area, respectively, in CCL20 mAb-treated rats at the injury epicenter and both rostral and caudal directions, respectively. ⁺ P < 0.05, compared with the sham group; ^* P < 0.05, compared with the CCL20 mAb group; &P < 0.05, compared with the isotype control group