Table 2.
n-3 PUFAs (Mean ± SD) | Placebo (Mean ± SD) | Mean Difference | 95 % CI, P-value | |
---|---|---|---|---|
Tibial nerve | ||||
DML 1 (ms) | 4.82 ± .81 | 5.80 ± 1.31 | −.98 | −1.50 to −.46, <.001* |
DML 2a | 4.60 ± .79 | 5.70 ± .95 | − .68 | − 1.18 to −.17, .009** |
% Changec | − 4.77 | − 1.73 | ||
a-CMAP1(mV) | 9.30 (5.62–13.72) | 10.20 (5.60–15.30) | -- | .696*** |
a-CMAP 2 | 10.20 (6.20–13.00) | 6.10 (3.47–9.25) | .003b | |
% Change | 9.68 | − 40.20 | ||
MCV 1(m/s) | 45.81 ± 6.61 | 43.06 ± 5.08 | 2.74 | −.05 to 5.54, .054* |
MCV 2 | 45.67 ± 6.18 | 42.34 ± 4.68 | 1.86 | − .52 to 4.25, .123** |
% Change | −.31 | − 1.70 | ||
Peroneal nerve | ||||
DML 1 (ms) | 4.34 ± .92 | 5.21 ± 1.44 | −.87 | −1.45 to −.30, .004* |
DML 2 | 4.16 ± 1.04 | 5.02 ± 1.95 | .08 | − .78 to .94, .850** |
% Change | − 3.93 | − 3.65 | ||
a-CMAP1(mV) | 4.00 (3.00–4.60) | 2.80 (1.90–5.20) | -- | .238*** |
a-CMAP 2 | 4.40 (3.10–5.30) | 2.90 (1.17–4.75) | .217b | |
% Change | 10.00 | 3.57 | ||
MCV 1(m/s) | 47.59 ± 5.95 | 44.07 ± 6.91 | 3.51 | .40 to 6.63, .028* |
MCV 2 | 44.70 ± 5.30 | 43.60 ± 6.87 | − 1.37 | − 3.88 to 1.14, .278** |
% Change | − 6.07 | −1.07 | ||
Ulnar nerve | ||||
DML 1 (ms) | 3.12 ± .61 | 3.35 ± .59 | −.23 | −.51 to .060, .118* |
DML 2 | 2.97 ± .55 | 3.33 ± .59 | − .26 | − .54 to .02, .073** |
% Change | − 4.81 | − .60 | ||
aCMAP1(mV) | 11.85 (9.40–14.30) | 12.40 (10.80–13.10) | -- | .394*** |
a-CMAP 2 | 13.10 (10.10–15.00) | 10.75 (10.00–13.60) | .033b | |
% Change | 10.55 | − 13.31 | ||
MCV 1(m/s) | 63.01 ± 26.22 | 55.60 ± 10.89 | 7.42 | −2.14 to 16.98, .126* |
MCV 2 | 53.64 ± 16.72 | 53.98 ± 6.34 | .07 | −6.84 to 6.97, .984** |
% Change | − 14.87 | − 2.90 |
DML distal motor latency, a-CMAP amplitude of compound muscle action potential, MCV motor conduction velocity
*P value is reported based on Independent-Samples T-Test
**P value is reported based on the analysis of covariance, adjusted for baseline values
***P value is reported based on the Mann–Whitney U Test
aOne month after the cessation of chemotherapy
b P value is reported based on the Mann–Whitney U Test (for changes of values during the intervention period)
cPercent change in proportion to the baseline values