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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Nat Med. 2016 Feb;22(2):128–134. doi: 10.1038/nm.4036

Figure 1. The PRC2 complex and its function in transcriptional regulation.

Figure 1

a. The mammalian PRC2 complex consists of four core subunits: the catalytic subunit enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED), suppressor of zeste 12 (SUZ12), and retinoblastoma (Rb)-associated protein 46/48 (RbAp46/48) and additional proteins, including AEBP2, PCL, and JARID2 have also at times been found to be associating with PRC2 complex to modulate the activity of PRC2 in different context. b. EZH2 regulates transcriptional activity: 1) EZH2 is also capable of methylating a number of non-histone protein substrates, 2) PRC2 methylates Histone 3 on lysine 27, which contributes to transcriptional silencing, 3) EZH2 also has a PRC2-independent role in transcriptional activation.