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Development of tumor metastases aided by the chemokine system. The process of tumor dissemination is depicted in seven steps: 1. Adhesion/rolling of leukocytes. 2. Transmigration of leukocytes. 3. Maturation of leukocytes. 4. Retention of leukocytes 5. Malignant transformation. 6. Malignant growth. 7. Metastases.
