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The BCR pathway has been targeted in CLL, at multiple different sites.
Abbreviations: BCR, B cell receptor signaling pathway; BTK, Bruton’s tyrosine kinase; CD, cluster of differentiation; CLL, chronic lymphocytic leukemia; mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3′-kinase; PLCγ2, phospholipase C gamma 2; SYK, spleen tyrosine kinase; NF-κB, nuclear factor-kappa B.
