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Autophagy negatively regulates type I interferon induction through multiple mechanisms.
Notes: (A) The Atg5–Atg12 complex blocks RLR–MAVS interaction. (B) Mitophagy eliminates reactive oxygen species (ROS)-containing mitochondria. (C) Atg9 controls the assembly of stimulator of interferon genes (STING) with TBK1 following its translocation from the endoplasmic reticulum (ER) to Golgi.
