Table 1.
NK cell activatory and inhibitory receptors
| Receptor type | Ligands | Signal type | Species |
|---|---|---|---|
| KIRs | HLA-A-C | Human | |
| KIR2DL1 | HLA-C2 | Inhibitory | |
| KIR2DL2/3 | HLA-C1 | Inhibitory | |
| KIR2DL4 | HLA-G | Activatory | |
| KIR2DL5 | Unknown | Inhibitory | |
| KIR3DL1 | HLA-Bw4 | Inhibitory | |
| KIR3DL2 | HLA-A3, -A11 | Inhibitory | |
| KIR2DS1 | HLA-C2 | Activatory | |
| KIR2DS2 | HLA-C1 | Activatory | |
| KIR2DS3 | Potentially HLA-C | Activatory | |
| KIR2DS4 | HLA-Cw4 and HLA-11 | Activatory | |
| KIR2DS5 | Unknown | Activatory | |
| KIR3DS1 | HLA-Bw4 | Activatory | |
| Ly49 | MHC class I | Mouse | |
| Ly49A | H-2Dd,k,p | Inhibitory | |
| Ly49C | H-2Kb,d, H-2Db,d,k | Inhibitory | |
| Ly49D | H-2Dd | Activatory | |
| Ly49H | m157 | Activatory | |
| Ly49I | H-2K/Db,d,s,q,v | Inhibitory | |
| Ly49P | H-2Dd | Inhibitory | |
| CD94-NKG2 | Human: HLA-E Mouse: Qa1b |
Human/mouse | |
| NKG2A | Inhibitory | ||
| NKG2C | Activatory | ||
| NKG2e | Activatory | ||
| NKG2D | Human: MIC-A/-B,ULBP1/2/3/4, RAe-1, MULT 1, H60 | Activatory | Human/mouse |
| NCRs | viral hemagglutinin | Human/mouse | |
| NKp30 | BAT-3, HSPG, B7-H6 | Activatory | |
| NKp44 | viral hemagglutinin | Activatory | |
| NKp46 | viral hemagglutinin, HSPG | Activatory | |
| NKp80 | AICL | Activatory | |
| LILR (ILT, LIR, CD85) | MHC class I, UL18 | Inhibitory | Human/mouse |
| 2B4 (CD244) | CD48 | Activatory/inhibitory | Human/mouse |
| KLRG1 | Cadherins | Inhibitory | Human/mouse |
| NKR-P1 | Ocil/Clr-b | Activatory/inhibitory | Mouse |
| PILR | CD99 | Activatory | Mouse |
| DNAM-1 | PVR CD122 |
Activatory | Human/mouse |
| CeACAM1 (CD66a or BGP) |
CeACAM1 CeACAM5 |
Inhibitory | Human/mouse |
| SIGLECC7/9 | Sialic acid | Inhibitory | Human |
| SIGLEC-E | Sialic acid | Inhibitory | Mouse |
Abbreviations: KIR, killer immunoglobulin-like receptor; RAE-1, retinoic acid early transcript-1; MULT 1, mouse UL16-binding-like transcript-1; NCR, natural cytotoxicity receptor; BAT-3, HLA-B-associated transcript 3; LILR, leukocyte immunoglobulin-like receptor; KLRG1, killer cell lectin-like receptor G1; CEACAM, carcinoembryonic antigen-related cell-adhesion molecule; PVR, polio virus receptor; NK, natural killer.