Figure 4.

Molecular characterization of MesA. (A) Schematic diagram of the insert from plasmid pCP1. Exons are depicted in blue. Coordinate number 1 refers to the A in the start codon. (B) Schematic depiction of MesA, showing conserved regions (red), potential transmembrane domains (purple), and dileucine motifs (black). (C) A cladogram depicting the evolutionary relationship between fungal MesA homologues. Ascomycete and basidiomycete lineages are shown in black and red, respectively. (D) Alignments of conserved domains (MH1–4) from MesA family members. The mesA1 mutation is located in the MH1 domain and is indicated by a red asterisk.