Table 3.
Independent predictors of overall survival
| Variables | Univariate
|
Multivariate
|
|
|---|---|---|---|
| P-value | P-value | Hazard ratio (95% CI) | |
| Demographic variables | |||
| Age | NS | ||
| Male sex | NS | ||
| Viral etiology | NS | ||
| ECOG 0–1, vs 2 | 0.006 | 0.210 | 1.3 (0.8–2.1) |
| Child-Pugh class B, vs A | 0.012 | 0.017 | 1.8 (1.1–3.1) |
| Tumor variables | |||
| Tumor size, ≥10 cm | 0.001 | 0.001 | 2.7 (1.6–4.7) |
| Multiple tumors, ≥4 | NS | ||
| Infiltrative tumor type, vs nodular | 0.058 | ||
| Portal vein invasion | <0.001 | <0.001 | 2.4 (1.5–3.8) |
| Presence of EHS and/or RNI | NS | ||
| Tumor markers | |||
| AFP non-response | <0.001 | 0.001 | 2.6 (1.5–4.3) |
| PIVKA-II non-response | NS | ||
Abbreviations: NS, not significant; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; EHS, extrahepatic spread; RNI, regional nodal involvement; AFP, α-fetoprotein; PIVKA-II, protein induced by vitamin K absence-II; vs, versus.