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. 2015 Jun 18;2:69–78. doi: 10.2147/JHC.S48505

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© 2015 Valero III et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Hepatocellular carcinoma development following YAP induction in a transgenic murine model.

Note: (A) Liver from YAP transgenic mouse model. Forced expression of the YAP protein for 2 months starting at 3 weeks after (A) or at (B) birth. Note the presence of discrete nodules throughout the liver (arrowheads). (C, D) Histolopathologic examination of murine liver nodules reveals characteristics of hepatocellular carcinoma. Arrow indicates cellular pleiomorphism by YAP induced HCC (C). Arrows show the loss of the cytoplasmic staining referred to as the clear cell change characteristic of HCC (D). Reprinted from Cell, 130(6), Dong J, Feldmann G, Huang J, et al, Elucidation of a universal size-control mechanism in Drosophila and mammals, 1120–1133, Copyright © 2007, with permission from Elsevier.¹²