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. 2015 Jun 26;2:91–99. doi: 10.2147/JHC.S48956

Figure 1.

Figure 1

Ligand-dependent and ligand-independent androgen receptor (AR)-activation in hepatocytes.

Abbreviations: CYP, cytochrome P450; TGF-β1, transforming growth factor β1; LXR, liver-X-receptor; VEGF, vascular endothelial growth factor; CCRK, cell cycle–related kinase; GRP78/Bip, glucose-regulated protein 78 kDa; ARE, androgen-responsive element; ARGs, androgen-responsive genes; MAPK/ERK, mitogen-activated protein kinase/extracellular signal–regulated protein kinase; STAT, signal-transducer and activator of transcription; AKT, v-akt murine thymoma viral oncogene homolog 1; IL-6, interleukin-6; IL-6R, interleukin-6 receptor; GP130, glycoprotein 130; P, phosphorylation.