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. 2015 Aug 10;6:7969. doi: 10.1038/ncomms8969

Figure 1. Design and effects of Toc-HDO.

Figure 1

(a) Schematic illustration of the construction of ASO, Toc-ASO and Toc-HDO. (b,c) The effects of Toc-HDO on ApoB mRNA levels in mouse liver 3 d after injection by qRT–PCR analyses. (b) After injection of 0.75 mg kg−1 ASO, HDO or Toc-HDO-targeting ApoB, shuffle sequence of Toc-HDO-targeting ApoB or Toc-HDO targeting an unrelated gene (n=3, mean values±s.e.m., *P<0.05, **P<0.01 versus PBS). (c) After injection of a different length of 0.75 mg kg−1 ASO or Toc-HDO-targeting ApoB (n=3, mean values±s.e.m., **P<0.01 versus PBS). (d) The effects of Toc-ASO on ApoB mRNA levels in mouse liver 3 d after injection of 0.75 or 3 mg kg−1 ASO- or Toc-ASO-targeting ApoB by qRT–PCR analyses (n=3, mean values±s.e.m., **P<0.01 versus PBS). Data are representative of at least three independent experiments each (b–d). P values were calculated from the Student's two-tailed t-test (b–d).