Figure 7.
NDV-HUJ induces immune memory against tumor cells in mice. Three months post tumor regression of mice treated with NDV-HUJ, the eight convalescent mice were challenged again with CT26-Luc cells.
Notes: The mice were observed under a charge coupled device camera at different times post CT26-Luc cell injection.42 (A) Naïve mice injected for the first time with CT26-Luc cells, developed tumor that progressed with time. (B) Seven of eight convalescent mice (treated with NDV-HUJ) were resistant to tumor development upon challenge with CT26-Luc cells. Minor tumor appearance was evident 5 days post cell injection (indicated by yellow arrow), that disappeared by day 12. (C) One of the eight convalescent mice developed a significant tumor post CT26-Luc challenge.
Abbreviations: NDV, Newcastle disease virus; HUJ, Hebrew University Jerusalem.