Table 3.
Adenovirus vectors tested in dogs with and without spontaneous tumors
Virus vector | Dogs (n) | Route | Outcome (n) | Authors, year |
---|---|---|---|---|
Recombinant Ad6 (two constructs) | Healthy (3–6) | Intramuscular | No detrimental effects | Peruzzi et al, 201046 |
Ad6-dTERT | Lymphoma (14) | Intramuscular | Prolonged survival time | Peruzzi et al, 201047 |
Ad-IFNγ | Astrocytoma (1) | Intratumoral | Prolonged survival time | Pluhar et al, 201048 |
AdCD40L | Oral melanoma (1) | Intratumoral | Complete remission (2) | von Euler et al, 200849 |
Dermal melanoma (1) | ||||
Melanoma (19) | Intratumoral | Complete remission (5) | Westberg et al, 201350 | |
Partial remission (8) | ||||
Stable disease (4) | ||||
Progressive disease (2) |