Table 3.
Adenovirus vectors tested in dogs with and without spontaneous tumors
| Virus vector | Dogs (n) | Route | Outcome (n) | Authors, year |
|---|---|---|---|---|
| Recombinant Ad6 (two constructs) | Healthy (3–6) | Intramuscular | No detrimental effects | Peruzzi et al, 201046 |
| Ad6-dTERT | Lymphoma (14) | Intramuscular | Prolonged survival time | Peruzzi et al, 201047 |
| Ad-IFNγ | Astrocytoma (1) | Intratumoral | Prolonged survival time | Pluhar et al, 201048 |
| AdCD40L | Oral melanoma (1) | Intratumoral | Complete remission (2) | von Euler et al, 200849 |
| Dermal melanoma (1) | ||||
| Melanoma (19) | Intratumoral | Complete remission (5) | Westberg et al, 201350 | |
| Partial remission (8) | ||||
| Stable disease (4) | ||||
| Progressive disease (2) |