Table 1.
Various oncolytic Sendai virus
| Oncolytic Sendai virus | Function |
|---|---|
| Genetic modified-Sendai virus | |
| SeV/ΔM | – Lack of production ability of infectious viral particles from infected cells |
| – Infection spread by cell–cell fusion of infected cells with uninfected cells | |
| MMP-sub SeV/ΔM | – Preferential infection to MMP-expressing cancer cells |
| uPA-sub SeV/ΔM | – Preferential infection to uPA-expressing cancer cells |
| Inactivated-Sendai virus | |
| UV-irradiated Sendai virus particle (HVJ-E) | – Induction of apoptosis in cancer cells by introduction of viral RNA genome fragments into cytoplasm |
| – Induction of necroptosis in cancer cell lack caspase-8 by HVJ-E membrane fusion | |
| – Activation of antitumor immunity (DCs stimulation, NK cells activation, Treg suppression) | |
| ΔHN-HVJ-E | – Low hemagglutinating activity |
| Tf/F-ΔHN-HVJ-E | – Transferrin receptor expressing cancer cell targeting |
| scIL12-HVJ-E | – Robust anticancer immune stimulation |
Abbreviations: ΔHN, hemagglutinin–neuraminidase-depleted; DCs, dendritic cells; HVJ-E, ultraviolet-irradiated hemagglutinating virus of Japan; MMP, matrix metalloproteinase; NK, natural killer; scIL12, single-chain interleukin-12; SeV/ΔM, recombinant hemagglutinating virus of Japan containing a viral genome lacking the M-coding region; sub, subtype; Tf/F, transferrin recombinant fusion protein; Treg, regulatory T-cell; uPA, urokinase-type plasminogen activator; UV, ultraviolet.