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. 2015 Aug 27;4:109–118. doi: 10.2147/OV.S66078

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© 2015 Hutzen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Summary of modifications introduced into MV-Edm through genetic engineering.

Notes: Location of the placement of the modifications within the genome is depicted. Functional contributions of the modifications are described as well. Descriptions of these recombinant viruses can be found in the text.

Abbreviations: MV-Edm, Edmonston strain of measles virus; GFP, green fluorescent protein; CEA, carcinoembryonic antigen; wt P, wild-type phosphoprotein; NIS, sodium iodide symporter; NAP, neutrophil-activating protein; PNP, purine nucleoside phosphorylase; GM-CSF, granulocyte macrophage colony-stimulating factor; a-PD-L1, anti-programmed death-1 ligand 1 antibody; a-CTLA-4, anti-cytotoxic T-lymphocyte antigen 4 antibody; ScFV, single chain fragment variable antibody.