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Monitoring reaction dynamics by varying CPR to CYP ratios in a reconstituted system: (A) Initial reaction conditions- [CYP2C9] = 100 nM, [NADPH] ~160 μM and [substrates] = 200 μM. Maximal NADPH autocatalytic rates under these conditions were ~0.1 nmoles/ml/min. CYP alone gave ~0.2 and CPR alone gave ~0.3 nmoles/ml/min, respectively. (B) Initial reaction conditions were [CYP2C9] = 100 nM, [NADPH] ~200 μM, and [substrates] = 200 μM.
