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. 2004 Aug;15(8):3841–3862. doi: 10.1091/mbc.E03-11-0794

Table 3.

Mutants used to confirm the wiring diagram (Figure 1) and to specify the parameter values (Table 2)

Wild-type
   In glucose
   In galactose
Cln mutants
   cln1Δ cln2Δ
   GAL-CLN2 cln1Δ cln2Δ
   cln1Δ cln2Δ sic1Δ
   cln1Δ cln2Δ cdh1Δ
   GAL-CLN2 cln1Δ cln2Δ cdh1Δ
   cln3Δ
   GAL-CLN3
Bck2 mutants
   bck2Δ
   Multi-copy BCK2
   cln1Δ cln2Δ bck2Δ
   cln3Δ bck2Δ
   cln3Δ bck2Δ GAL-CLN2 cln1Δ cln2Δ
   cln3Δ bck2Δ multi-copy CLN2
   cln3Δ bck2Δ sic1Δ
cln1 cln2 cln3 strain
   cln1Δ cln2Δ cln3Δ
   cln1Δ cln2Δ cln3Δ GAL-CLN2
   cln1Δ cln2Δ cln3Δ GAL-CLN3
   cln1Δ cln2Δ cln3Δ sic1Δ
   cln1Δ cln2Δ cln3Δ cdh1Δ
   cln1Δ cln2Δ cln3Δ multi-copy CLB5
   cln1Δ cln2Δ cln3Δ GAL-CLB5
   cln1Δ cln2Δ cln3Δ multi-copy BCK2
   cln1Δ cln2Δ cln3Δ GAL-CLB2
   cln1Δ cln2Δ cln3Δ apcts
Cdh1, Sic1 and Cdc6 mutants
   sic1Δ
   GAL-SIC1
   GAL-SIC1-dbΔ
   GAL-SIC1 cln1Δ cln2Δ
   GAL-SIC1 GAL-CLN2 cln1Δ cln2Δ
   GAL-SIC1 cln1Δ cln2Δ cdh1Δ
   GAL-SIC1 GAL-CLN2 cln1Δ cln2Δ cdh1Δ
   cdh1Δ(*)
   Cdh1 constitutively active
   sic1Δ cdh1Δ(*)
   sic1Δ cdh1Δ GALL-CDC20
   cdc6Δ2-49
   cdc6Δ2-49 sic1Δ
   cdc6Δ2-49 cdh1Δ(*)
   cdc6Δ2-49 sic1Δ cdh1Δ(*)
   cdc6Δ2-49 sic1Δ cdh1Δ GALL-CDC20
   swi5Δ
   swi5Δ GAL-CLB2
   swi5Δ cdh1Δ(*)
   swi5Δ cdh1Δ GAL-SIC1
Clb1 Clb2 mutants
   clb1Δ clb2Δ
   clb2Δ CLB1(*)
   GAL-CLB2
   Multi-copy GAL-CLB2
   clb2Δ CLB1 cdh1Δ(*)
   clb2Δ CLB1 pds1Δ(*)
   GAL-CLB2 sic1Δ(*)
   GAL-CLB2 cdh1Δ
   CLB2-dbΔ
   CLB2-dbΔ in galactose
   CLB2-dbΔ multi-copy SIC1
   CLB2-dbΔ GAL-SIC1
   CLB2-dbΔ multi-copy CDC6
   CLB2-dbΔ clb5Δ
   CLB2-dbΔ clb5Δ in galactose
   GAL-CLB2-dbΔ
Clb5 Clb6 mutants
   clb5Δ clb6Δ
   clb5Δ clb6Δ cln1Δ cln2Δ
   GAL-CLB5
   GAL-CLB5 sic1Δ
   GAL-CLB5 cdh1Δ
   CLB5-dbΔ
   CLB5-dbΔ sic1Δ
   CLB5-dbΔ pds1Δ
   CLB5-dbΔ pds1Δ cdc20Δ
   GAL-CLB5-dbΔ
Cdc20 mutants
   cdc20ts
   cdc20Δ clb5Δ
   cdc20Δ pds1Δ
   cdc20Δ pds1Δ clb5Δ
   GAL-CDC20
   cdc20ts mad2Δ
   cdc20ts bub2Δ
Pds1/Esp1 interaction
   pds1Δ(*)
   esp1ts
   PDS1-dbΔ
   GAL-PDS1-dbΔ
   GAL-PDS1-dbΔ esp1ts
   GAL-ESP1 cdc20ts
MEN pathway mutants
   tem1Δ
   GAL-TEM1
   tem1ts multi-copy CDC15
   tem1ts GAL-CDC15
   tem1Δ net1ts
   tem1Δ multi-copy CDC14
   cdc15Δ
   Multi-copy CDC15
   cdc15ts multi-copy TEM1
   cdc15Δ net1ts
   cdc15ts multi-copy CDC14
Exit-of-mitosis mutants
   net1ts
   GAL-NET1
   cdc14ts
   GAL-CDC14
   GAL-CDC14 GAL-NET1
   net1ts cdc20ts
   cdc14ts GAL-SIC1
   cdc14ts then GAL-SIC1
   cdc14ts sic1Δ at permissive temperature
   cdc14ts cdh1Δ at permissive temperature
   cdc14ts GAL-CLN2 at permissive temperature
   TAB6-1
   TAB6-1 cdc15ts
   TAB6-1 clb5Δ
   TAB6-1 clb2Δ CLB1
Checkpoint mutants
   mad2Δ
   bub2Δ
   mad2Δ bub2Δ
   WTI in nocodazole
   mad2Δ in nocodazole
   mad2Δ GAL-TEM1 in nocodazole
   mad2Δ pds1Δ in nocodazole
   bub2Δ in nocodazole (*)
   bub2Δ pds1Δ in nocodazole
   bub2Δ mad2Δ in nocodazole
   pds1Δ in nocodazole
   net1ts in nocodazole
APC mutants
   APC-A
   APC-A cdh1Δ
   APC-A cdh1Δ in galactose
   APC-A cdh1Δ multi-copy SIC1
   APC-A cdh1Δ GAL-SIC1
   APC-A cdh1Δ multi-copy CDC6
   APC-A cdh1Δ GAL-CDC6
   APC-A cdh1Δ multi-copy CDC20
   APC-A sic1Δ
   APC-A GAL-CLB2
(*)

indictes 11 mutants whose simulations do not agree with experimental observations