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α‐hairpin repeat domains in ECOD. (A) Alpha internal repeat domains in ECOD from the HEAT, TPR, and Armadillo repeats are classified as homologs. (B) The ankyrin domains are classified as possibly homologs to ARM/HEAT/TPR domains. (C) Alpha/alpha toroids, such as farnesyltransferase, are alpha‐hairpin repeats that are closed, rather than open, and not as easily expanded by axial duplication.
