Figure 6.

Diverse topologies of the β‐propellers. Examples of non‐canonical topologies in the β‐propeller homologs group. (A) One blade of the deteriorated propeller domain of adsorption PRD1 P2 (e1n7vA1) has been replaced with a novel β domain with complex topology (e1n7vA2). (B) The luminal domain of endoribonuclease IRE1 (e2be1A1) is topologically dissimilar to other β‐propellers, but strong sequence homology to propeller repeats is detected between IRE1 and other canonical propellers. (C) PH1500 is 12‐bladed propeller composed of a hexamer of double propeller repeats, both an obligate multimer and composed of internal repeats (PDB: 2m3x).