Comparison of domain definitions between ECOD and Pfam. (A) The distribution of Pfam family coverage on a nonredundant set of ECOD domains that have a one‐to‐one mapping to Pfam families. (B) Mapping of Pfam family XPG_N (PF00752, blue) and XPG_I (PF00867, orange) on RAD2 structure (PDB: 4q0w). (C) Mapping of HAD‐related domain (e4q0wA2, pink) and SAM‐like domain (e4q0wA1, cyan) from ECOD on the same structure. Side chains of catalytic residues are shown in stick, with the coordinating calcium ion in green sphere. (D) Top 20 H‐groups where split Pfam families are assigned.