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The relationship between organismal fitness (W) and a protein's functional output, or protein fitness (W P), that is, the level of soluble, functional protein in the cell multiplied by its specific activity (e.g., enzymatic k cat /K M, or k cat). Both fitness values are given as relative, that is, taking the value of 1 for the wild‐type protein and organism. The simulated graphs follow Eq. (2) with the buffering coefficient (B) taking the values of 0.01 up to 1.
