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. 2016 Feb 11;25(7):1168–1178. doi: 10.1002/pro.2886

Figure 1.

Figure 1

Aspects of protein biochemistry/biophysics on which selective pressures may act are depicted. (1) Stability of the folded state; (2) protein aggregation; (3) misfolding and kinetic traps; (4) nonspecific binding or change in the binding partner at the native site; (5) binding at a new site; (6) concentration levels of the protein; (7) kinetic motions of the protein. Images obtained from the RSCB PDB (www.rscb.org)2 of PDB ID 2MRK,3 PDB ID 1KA5,4 and Foldit.5