Table 3.

Summary of different classes of molecules delivered by HDL and their targets.

Category	Molecules delivered by HDL	HDL composition	Target	Activity	Particle size	References
Small molecules	Statin	ApoA1/lipids	Cardiovascular system	Inflammation inhibition in the atherosclerotic plaques	10 - 30 nm	102
	Sphingosine-1-phosphate (S1P)	Endogenous HDL	Cardiovascular system	Promoting endothelial barrier function	~ 10 nm	103
	Adefovir	Lactosylated HDL apoproteins	Liver	HBV inhibition in hepatocytes	~ 11 nm	104
	Amphotericin B	ApoA1/lipids	Fungi	Antifungal drugs	~ 8.5 nm	105
	10-Hydroxycamptothecin (10-HCPT)	ApoA1/lipids	Tumor	Anticancer drugs	~ 25 nm	106
	All trans retinoic acid (ATRA)	ApoA1/lipids	Tumor	Anticancer drugs	N.A.	107
	Curcumin	ApoA1/lipids	Tumor	Anticancer drugs	< 50 nm	108, 109
	Paclitaxel	ApoA1/lipids	Tumor	Anticancer drugs	7.4 - 20.7 nm	110, 111
	Doxorubicin	ApoA1/lipids	Tumor	Anticancer drugs	~ 20 nm	112
	MPLA	ApoA1/lipids	Immune system	TLR4 agonist	~ 15 nm	113
Peptides/p roteins	Nosiheptide	ApoA1/lipids	Liver	HBV inhibition in hepatocytes	< 30 nm	114
	Cytochrome C	ApoA1/lipids	Tumor	Anticancer drugs	20-30 nm	115
	α-melittin	ApoA mimetic peptides/lipids	Tumor	Anticancer drugs	~ 15 nm	116
	Hemagglutinin 5 (H5)	ApoA1/lipids	Immune system	Protein Antigens from virus	~ 15 nm	117
	Yersinia pestis LcrV	ApoA1/lipids	Immune system	Protein Antigens from bacteria	~ 15 nm	118
Nucleic acids	ApoB siRNA	Endogenous HDL; ApoA1/lipids; ApoE/lipids	Liver	Knockdown of ApoB lipoprotein	~ 10 nm	72
	ApoM siRNA	Endogenous HDL	Liver	Knock down of ApoM lipoprotein	~ 10 nm	72
	PCSK9 siRNA	ApoE/lipids	Liver	LDL receptor upregulation	~ 10 nm	119
	STAT3 siRNA	ApoA1/lipids	Tumor	Tumor growth inhibition	~ 10 nm	120
	BCL2 siRNA	ApoA1 mimetic peptides/lipids	Tumor	Tumor growth inhibition	~ 25 nm	74
	OAT3 siRNA	Endogenous HDL	Brain Capillary Endothelial Cells (BCEC)	Knockdown of organic anion transporter 3 (OAT3)	~ 10 nm	121
	CpG (single stranded DNA)	ApoA1/lipids	Immune system	TLR9 agonist	~ 15 nm	113