Figure 4.
Effects of MSP injection and itr-1 RNAi in rrf-1(pk1417) worms on sheath contractility. (A) Rates of basal sheath contraction in itr-1(sa73) and fog-2(q71) mutant worms after injection of water or an MSP C-terminal peptide (MSP CT) into the uterus via the vulva. Values are means ± SE (n = 11–17). *p < 0.0001 compared with water injected fog-2(q71) worms. (B) Basal and peak ovulatory contraction rates in wild-type and rrf-1(pk1417) worms fed itr-1 dsRNA beginning at the L1 larval stage. Ovulatory contractions were not detected in wild-type RNAi worms. Values are means ± SE (n = 4–11). *p < 0.001 compared with wild type.