Figure 4.
Evaluation of histopathological alterations in the ischemic penumbra and the core zone by H&E staining. (A-C) H&E staining presenting gross histopathological alterations in normal, ischemic penumbra and the ischemic core at 12, 24 and 72 h post-reperfusion in the three groups. Black arrows indicate nuclear shrinkage, and the red arrows indicate neuronal vacuolization. Magnification, ×300. Scale bar =50 µm. H&E, hematoxylin and eosin; S, sham; IR, ischemia-reperfusion; I, z-fluoromethylketone.