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. 2016 May 10;14(1):49–56. doi: 10.3892/mmr.2016.5233

Figure 1.

Figure 1

CLI-095 attenuates the development of atherosclerotic lesions in ApoE−/− mice. (A) Serum total cholesterol and triglyceride levels were measured. (B) En face Oil-red-O staining of the thoracic aorta, and quantification of plaque area. ●, Chow diet (n=5); ■, high-fat diet (n=5); □, high-fat diet + CLI-095 (n=5). Magnification, ×4. (C) Representative photomicrographs of Oil-red-O, H&E and Masson's trichrome staining from mice with comparable lesion sizes. Results are presented as the mean ± standard deviation. Magnification, ×10 and ×40 (bottom row). *P≤0.05; **P≤0.01; ***P≤0.001. ApoE−/−, apolipoprotein E-deficient; H&E, hematoxylin and eosin.