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. 2016 May 10;14(1):49–56. doi: 10.3892/mmr.2016.5233

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CLI-095 reduces macrophage foam cell formation. (A) Decreased uptake of Ox-LDL in CLI-095-treated MPMs (1 μM) compared with vehicle-treated MPMs. Right graph shows quantification of foam cells. (B) Expression of Lox-1 in MPMs was assessed by confocal immunofluorescence and immunoblotting. The lower-right panel shows densitometric quantification. Magnification, ×100. Results are presented as the mean ± standard deviation (n=3). ^*P≤0.05; ^**P≤0.01; ^***P≤0.001. MPMs, murine peritoneal macrophages; Ox-LDL, oxidized low-density lipoprotein; Lox-1, lectin-like oxidized low-density lipoprotein receptor-1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; DAPI, 4′6-diamidino-2-phenylindole.