Skip to main content
. 2016 May 10;14(1):49–56. doi: 10.3892/mmr.2016.5233

Figure 4.

Figure 4

CLI-095 decreases the level of cholesteryl ester in MPMs by regulating the expression of ABCA1 and ACAT-1. (A) Cholesteryl ester content in CLI-095- and vehicle-treated MPMs incubated with Ox-LDL (100 μg/ml) (n=3). (B) Ratio of cellular cholesteryl ester and total cholesterol in MPMs (n=3). (C–E) Western blot analysis of (C) TLR4 expression, (D) NF-κB P65 phosphorylation, (E) ABCA1 expression and (F) ACAT-1 expression in CLI-095- and vehicle-treated MPMs incubated with Ox-LDL (100 μg/ml) (n=3). Results are presented as the mean ± standard deviation (n=3). *P≤0.05; **P≤0.01; ***P≤0.001. MPMs, murine peritoneal macrophages; ABCA1, ATP-binding cassette transporter A1; ACAT-1, acyl-coenzyme A:cholesterol acyltransferase-1; NF-κB, nuclear factor-κB; TLR4, toll-like receptor 4; Ox-LDL, oxidized low-density lipoprotein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.