Table II.
Molecular details and pathological findings in the HM samples.
| Patient no. | Pathological findings | FISH | STR | Array-SNP | Final diagnosis |
|---|---|---|---|---|---|
| 1 | The majority of the villi exhibited marked edema | Normal | Complete homozygosity across all STR markers | Arr (1–22, X)×2 hmz | CHM |
| 2 | CHM | Normal | Complete homozygosity across all STR markers | Arr (1–22, X) ×2 hmz | CHM |
| 3 | PHM | Normal | Complete homozygosity across all STR markers | Arr (1–22, X) ×2 hmz Co-twins: Normal | Twins + CHM |
| 4 | PHM | Trisomy 13 | Trisomy 13 Co- twins: Trisomy 13 | Twins + PHM | |
| 5 | Edema villi tissue | Triploid (69, XXX) | Triploid (69, XXX) | PHM | |
| 6 | A section of the villi exhibited interstitial edema | Tetraploidy (XXYY) | Abnormal genotype for whole genome | PHM | |
| 7 | Part of the villi exhibited interstitial edema, although trophoblastic hyperplasia is not evident | Triploid (69, XXX) | Triploid (69, XXX) | PHM | |
| 8 | PHM | Triploid (69, XXX)+16 | PHM | ||
| 9 | A section of the villi exhibited interstitial edema | Not detected | Trisomy 20 | PHM |
FISH, fluorescence in situ hybridization; CHM, complete hydatidiform mole; PHM, partial hydatidiform mole; STR, short tandem repeat; SNP, single nucleotide polymorphism.