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. Author manuscript; available in PMC: 2016 Jun 23.
Published in final edited form as: Lab Chip. 2010 Jan 20;10(8):991–998. doi: 10.1039/b918719g

Figure 6.

Figure 6

Live microscopy of thrombus retraction forces. (A) Top row: phase-contrast images of thrombus formation obtained at selected time points. Outline of the clot is shown by yellow trace. Bottom row: fluorescent images of post deflections were used to measure contractile force vectors simultaneously with monitoring of thrombus formation. The clot is not visible under fluorescence, but its outline is shown to illustrate the structural changes in clot formation that accompany the dynamics of contraction force generation. (B) Total force development with time for six clots. Upon thrombin activation at the 25-min mark (arrowhead), all clots exhibit a measureable contractile response. (C) Averaging the total force for all clots in pane B reveals a contractile rate that is similar to the quasi-static measurements shown previously.