Table 1. Clinical diagnostic criteria for neurofibromatosis type 1.

Diagnostic criteria of NF1
Two or more of the following:
• At least six café-au-lait macules (> 5 mm diameter in prepubertal individuals and > 15 mm in postpubertal individuals)
• Freckling in axillary or inguinal regions
• Optic glioma
• At least two Lisch nodules (iris hamartomas)
• At least two neurofibromas of any type, or one plexiform neurofibroma
• A distinctive osseous lesion (sphenoid dysplasia or tibial pseudarthrosis)
• A first degree relative with NF1