Table 1. Major clinical manifestations of the PRO spectrum.

Disorder	Major clinical manifestations
MCAP	Macrocephaly, capillary malformations, brain overgrowth, distal limb defects, mental disability
CLOVES	Mixed vascular malformations, adipose tissue overgrowth, scoliosis and skeletal overgrowth
FAO/HMML	Progressive segmental overgrowth of fibrous and adipose tissue and bone
ILM	Large lymphatic malformation limited to a single body site and without associated symptoms
Macrodactyly	Localized overgrowth of a single or a few digits
Hemimegalencephaly	Overgrowth of one cerebral hemisphere
Muscle hemihyperplasia	Asymmetric muscular overgrowth
Facial infiltrating lipomatosis	Diffuse infiltration of facial tissues by mature adipose tissue
Epidermal nevi	Congenital verrucous skin plaques following Blaschko lines
Seborrheic keratosis	Localized verrucous plaque occurring later in life, usually round and dark brown
Benign lichenoid keratosis	Considered as a variant of seborrheic keratosis, flat red-brown skin plaque

Abbreviations: CLOVES, capillary malformations, lipomatous overgrowth of adipose tissue, and scoliosis; FAO/HMML, fibroadipose overgrowth/hemihyperplasia-multiple lipomatosis; ILM, isolated large lymphatic malformation; MCAP, macrocephaly-capillary malformation.

Source: Adapted from Keppler-Noreuil et al.³²