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. 1975 Feb;38(2):123–128. doi: 10.1136/jnnp.38.2.123

Monoamine acid metabolites and cerebrospinal fluid dynamics in normal pressure hydrocephalus: preliminary results.

G Maira, S R Bareggi, C Di Rocco, G Calderini, P L Morselli
PMCID: PMC491874  PMID: 1151392

Abstract

Lumbar and ventricular CSF concentration of homovanillic acid (HVA) and 5-hydroxy-indole-acetic acid (5-HIAA) have been determined in 13 patients admitted to hospital for suspected normal pressure hydrocephalus. Low values of HVA in lumbar CSF were found in all patients with reduced CSF absorption and CSF flow inversion. The HVA lumbar concentration remained low after shunt procedure; it increased if obstruction of the shunt occurred. The ventricular CSF concentration of HVA was normal before surgery; it became higher, in two cases, after surgery. No important variations were found in the lumbar and ventricular CSF concentration of 5-HIAA. The possible mechanisms and diagnostic value of these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS R. D., FISHER C. M., HAKIM S., OJEMANN R. G., SWEET W. H. SYMPTOMATIC OCCULT HYDROCEPHALUS WITH "NORMAL" CEREBROSPINAL-FLUID PRESSURE.A TREATABLE SYNDROME. N Engl J Med. 1965 Jul 15;273:117–126. doi: 10.1056/NEJM196507152730301. [DOI] [PubMed] [Google Scholar]
  2. Andersson H., Roos B. E. 5-hydroxyindoleacetic acid in cerebrospinal fluid of hydrocephalic children. Acta Paediatr Scand. 1969 Nov;58(6):601–608. doi: 10.1111/j.1651-2227.1969.tb04768.x. [DOI] [PubMed] [Google Scholar]
  3. Andersson H., Roos B. E. Increased level of 5-hydroxyindoleacetic acid in cerebrospinal fluid from infantile hydrocephalus. Experientia. 1966 Aug 15;22(8):539–540. doi: 10.1007/BF01898679. [DOI] [PubMed] [Google Scholar]
  4. Bulat M., Zivković B. Origin of 5-hydroxyindoleacetic acid in the spinl fluid. Science. 1971 Aug 20;173(3998):738–740. doi: 10.1126/science.173.3998.738. [DOI] [PubMed] [Google Scholar]
  5. Curzon G., Gumpert E. J., Sharpe D. M. Amine metabolites in the lumbar cerebrospinal fluid of humans with restricted flow of cerebrospinal fluid. Nat New Biol. 1971 Jun 9;231(23):189–191. doi: 10.1038/newbio231189a0. [DOI] [PubMed] [Google Scholar]
  6. Epstein F., Hochwald G., Ransohoff J. A volume control system for the treatment of hydrocephalus: laboratory and clinical experience. J Neurosurg. 1973 Mar;38(3):282–287. doi: 10.3171/jns.1973.38.3.0282. [DOI] [PubMed] [Google Scholar]
  7. Garelis E., Sourkes T. L. Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):625–629. doi: 10.1136/jnnp.36.4.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hakim S., Adams R. D. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci. 1965 Jul-Aug;2(4):307–327. doi: 10.1016/0022-510x(65)90016-x. [DOI] [PubMed] [Google Scholar]
  9. Hochwald G. M., Lux W. E., Jr, Sahar A., Ransohoff J. Experimental hydrocephalus. Changes in cerebrospinal fluid dynamics as a function of time. Arch Neurol. 1972 Feb;26(2):120–129. doi: 10.1001/archneur.1972.00490080038003. [DOI] [PubMed] [Google Scholar]
  10. Korf J., van Praag H. M., Sebens J. B. Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid. Biochem Pharmacol. 1971 Mar;20(3):659–668. doi: 10.1016/0006-2952(71)90152-3. [DOI] [PubMed] [Google Scholar]
  11. Lorenzo A. V., Hammerstad J. P., Cutler R. W. Cerebrospinal fluid formation and absorption and transport of iodide and sulfate from the spinal subarachnoid space. J Neurol Sci. 1970 Mar;10(3):247–258. doi: 10.1016/0022-510x(70)90153-x. [DOI] [PubMed] [Google Scholar]
  12. Lorenzo A. V., Page L. K., Watters G. V. Relationship between cerebrospinal fluid formation, absorption and pressure in human hydrocephalus. Brain. 1970;93(4):679–692. doi: 10.1093/brain/93.4.679. [DOI] [PubMed] [Google Scholar]
  13. Moir A. T., Ashcroft G. W., Crawford T. B., Eccleston D., Guldberg H. C. Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain. Brain. 1970;93(2):357–368. doi: 10.1093/brain/93.2.357. [DOI] [PubMed] [Google Scholar]
  14. Rossi G. F., Galli G., Di Rocco C., Maira G., Meglio M., Troncone L. Normotensive hydrocephalus. The relations of pneumoencephalography and isotope cisternography to the results of surgical treatment. Acta Neurochir (Wien) 1974;30(1-2):69–83. doi: 10.1007/BF01405756. [DOI] [PubMed] [Google Scholar]
  15. Sypert G. W., Leffman H., Ojemann G. A. Occult normal pressure hydrocephalus manifested by parkinsonism-dementia complex. Neurology. 1973 Mar;23(3):234–238. doi: 10.1212/wnl.23.3.234. [DOI] [PubMed] [Google Scholar]

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