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. Author manuscript; available in PMC: 2017 May 21.
Published in final edited form as: Curr Opin Genet Dev. 2016 May 21;37:137–147. doi: 10.1016/j.gde.2016.04.005

FIGURE 1.

FIGURE 1

A) XIST RNA is expressed from and coats the silent interphase X-chromosome territory in cis, and can be seen as a large RNA signal in the three color image at left and the separated channel to the right. The RNA initiates a cascade of chromatin modifications at both protein and DNA levels (including histone modifications as seen in the three color image and separated channel at right) as well as architectural changes to form the heterochromatic Barr Body (see arrow in the separated DAPI channel at right). B) The Barr Body structure is striking in some cell preparations, including for this autosome (chromosome 4) carrying an XIST transgene.