Table 1.
Peak Methamphetamine Effects on the VAS and Drug-Effect Questionnaire
| Methamphetamine conditions | |||||||
|---|---|---|---|---|---|---|---|
| Measure | Pbo Mean (SEM) |
12 mg | 25 mg | 50 mg | |||
| Mean (SEM) | F-Value | Mean (SEM) | F-Value | Mean (SEM) | F-Value | ||
| Items on which methamphetamine increased VAS ratings | |||||||
| Alert | 58.36 (8.36) | 76.00 (7.54) | 8.87* | 75.00 (5.92) | 7.89* | 87.55 (4.07) | 24.27*† |
| Content | 57.64 (7.09) | 56.18 (3.61) | 0.07 | 59.64 (4.72) | 0.13 | 72.27 (5.42) | 6.83*§† |
| Energetic | 40.18 (10.54) | 61.46 (9.33) | 6.05* | 62.09 (8.56) | 6.42* | 71.55 (6.42) | 13.15* |
| Forgetful | 13.55 (6.88) | 11.55 (6.28) | 0.07 | 20.09 (7.01) | 0.78 | 28.91 (11.64) | 5.51§ |
| Good drug effect | 4.36 (1.45) | 46.46 (10.92) | 21.04* | 58.27 (6.62) | 34.51* | 78.64 (5.41) | 65.51*§† |
| Heart beating faster | 11.27 (5.72) | 27.18 (10.25) | 3.54 | 31.82 (10.30) | 5.90* | 43.18 (11.87) | 14.23* |
| High | 7.00 (2.41) | 42.18 (8.93) | 16.69* | 55.82 (6.43) | 32.13* | 73.18 (7.21) | 59.04*§† |
| Jittery | 7.36 (3.66) | 22.73 (9.42) | 4.38* | 14.73 (7.85) | 1.01 | 24.82 (8.56) | 5.65* |
| Nose burning | 2.60 (1.26) | 10.50 (7.02) | 0.90 | 23.70 (8.24) | 6.42* | 28.00 (9.28) | 9.30*§ |
| Stimulated | 14.46 (7.50) | 43.55 (9.15) | 11.12* | 56.36 (6.22) | 23.08* | 78.64 (5.78) | 54.14*§† |
| Sweating | 2.09 (0.99) | 10.73 (8.07) | 1.04 | 17.91 (7.40) | 3.49 | 25.09 (7.50) | 7.39* |
| Talkative | 57.27 (6.67) | 66.27 (5.85) | 2.02 | 66.27 (6.59) | 1.82 | 77.09 (6.21) | 9.79* |
| Items on which methamphetamine decreased VAS ratings | |||||||
| Hunger | 70.27 (8.24) | 27.73 (7.94) | 23.15* | 12.82 (6.96) | 42.23* | 10.82 (4.46) | 45.22* |
| Irritable | 37.55 (10.62) | 24.73 (7.85) | 2.41 | 36.82 (9.63) | 2.91 | 18.27 (7.75) | 5.45*† |
| Sleepy | 74.64 (10.47) | 33.64 (10.64) | 13.79* | 33.82 (11.03) | 13.67* | 28.27 (8.78) | 17.64* |
| Tired | 72.09 (11.11) | 44.73 (9.99) | 8.63* | 27.73 (10.90) | 22.69* | 32.55 (8.36) | 18.03* |
| Unmotivated | 45.73 (12.13) | 22.46 (9.59) | 3.91 | 25.46 (11.12) | 2.97 | 13.36 (5.74) | 7.56* |
| MA craving | 79.00 (10.11) | 71.80 (11.62) | 2.84 | 70.00 (11.53) | 4.44* | 71.30 (11.80) | 3.25 |
| Drug-effect questionnaire | |||||||
| Drug liking | 0.09 (0.09) | 1.09 (0.39) | 5.43* | 1.82 (0.42) | 16.21* | 2.36 (0.47) | 28.07*§ |
| Drug strength | 0.18 (0.12) | 1.00 (0.19) | 6.60* | 2.00 (0.33) | 32.61*§ | 2.00 (0.38) | 32.61*§ |
| Good effects | 0.09 (0.09) | 1.18 (0.26) | 8.28* | 2.00 (0.41) | 25.35*§ | 2.46 (0.39) | 38.85*§ |
Abbreviations: Pbo, Placebo; VAS, visual analog scale; MA, methamphetamine.
*
P < 0.05, significantly different from placebo.
§
P < 0.05, significantly different from 12 mg.
†
P < 0.05, significantly different from 25 mg.