Figure 4.

Chronic cannabinoid treatment during the late-adolescence period reduces anxiety-like behavior in an open field test. (A) Males administered with chronic WIN during the late-adolescence period demonstrated less anxiety in the open field test in adulthood compared with vehicle treated males. (B) No significant differences between the male groups in activity levels were found. (C) Females administered with chronic WIN during the late-adolescence period demonstrated less anxiety in the open field test in adulthood compared with vehicle treated females. (D) No significant differences between the female groups in activity levels were found. (*P < 0.05; **P < 0.01).