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. 2016 Jul;23(7):359–364. doi: 10.1101/lm.042507.116

Figure 1.

Figure 1.

Acquisition and serial reversal of an IntelliCage place-learning task in NAc RNB mice. (A) WT (n = 9) and NAc D1-RNB (n = 8) mice did not significantly differ in acquisition and reversal learning of shuttling responses in the place-learning task. (B) NAc D2-RNB (n = 8) mice showed normal acquisition, but impaired reversal learning of the place-learning task when compared with WT (n = 7) mice. (*) P < 0.05, significant main effect of genotype in the first reversal stage (Rev 1). Decreased percentage of correct responses in D2-RNB mice was restored to the level of WT mice by the third reversal stage (Rev 3). Small boxes at the bottom represent an example of the IntelliCage setup for each stage, with filled circles indicating the reward-paired corners and empty circles indicating the non-reward-paired corners. Graph points represent the mean responses for each genotype, with error bars indicating ±SEM.