Table 1.

Cardiac and skeletal muscle functions of Popdc proteins.

Function	Reference
POPDC genes are predominantly expressed in striated muscle	[1]
Popdc1−/− mice display a reduction in the number and an increase in the size of caveolae	[33]
Popdc1−/− mice display an increased vulnerability to ischemia-reperfusion injury	[33]
Popdc1 controls membrane trafficking of TREK-1	[10]
Popdc1 or Popdc2 null mutant mice display an age-dependent stress-induced bradycardia phenotype	[10]
Depletion of either Popdc1 or Popdc2 in mice results in structural remodelling of SAN tissue	[10]
Depletion of popdc1 or popdc2 in zebrafish causes AV-block and muscular dystrophy	[9,12]
Popdc1 in zebrafish controls the formation of the myotendinous junction	[12]
The missense mutation POPDC1S191F causes cardiac arrhythmia and muscular dystrophy in patients	[12]
POPDC1 and POPDC3 are downregulated in human heart failure	[40]
POPDC1 has been associated with atrial fibrillation	[38]
POPDC1 is a novel genetic determinant of the QT interval and the QRS time	[39]