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. Author manuscript; available in PMC: 2016 Jun 23.
Published in final edited form as: Cold Spring Harb Symp Quant Biol. 2016 Jan 13;80:281–288. doi: 10.1101/sqb.2015.80.027573

Fig. 6. Of the specific-specific regulation of human biological processes by KRAB-ZFPs and their TE targets.

Fig. 6

TEs sprinkle the human genome with sequences largely unique to this species both in sequence and genomic location. These TE sequences are used as landing platforms for KRAB-ZFPs, which themselves display limited levels of orthology with similar proteins from other species. A triply species-restricted regulatory layer is thus laid over canonical, conserved transcription pathways. The impact of this phenomenon on speciation might be particularly pronounced in organs subjected to environmental constraints that are not overly coercive, such as the brain.