. Author manuscript; available in PMC: 2016 Jun 23.

Published in final edited form as: Clin Cancer Res. 2007 Dec 15;13(24):7401–7406. doi: 10.1158/1078-0432.CCR-07-0781

Table 4.

Brain tumor concentrations of temsirolimus and sirolimus

Dose (group)	Whole blood concentration, ng/mL (TEM/SIR)	Time (h) from BOI to tumor acquisition	Tumor concentration, ng/g dry weight (TEM/SIR)	Tissue/blood ratio (TEM/SIR)
170 mg (A)	108/133	5.1	129/BLD	1.19/BLD
170 mg (A)	150/164	5.0	213/86	1.42/0.52
250 mg (B)	290/70	2.7	200/127	0.69/1.81
250 mg (B)	207/35	5.6^*	192/22	0.93/0.63
250 mg (B)	127/96	3.8	428/61	3.37/0.63
250 mg (B)	162/86	5.4	155/50	0.97/0.58

NOTE: A, non-EIAED group; B, EIAED group.

Abbreviations: BOI, beginning of infusion; BLD, below limit of detection.

Three and a half hours between whole blood and tumor acquisition.