Table 2.
Antibody (Ab) Titer and Placental Transfer Ratio (TR) of Dengue Virus (DENV)–Specific Immunoglobulin G (IgG), DENV-1–4 Serotype–Specific Neutralizing Abs, and DENV-Specific IgG1 and IgG4 Subclasses in 376 Pairs of Maternal and Umbilical Cord Blood Samples
| Serologic Variable | Maternal Sera (n = 376) |
Cord Sera (n = 376) |
TR,b % | P Valuec | ||
|---|---|---|---|---|---|---|
| Positive, No. (%) | Ab Titer,a Mean ± SD | Positive, No. (%) | Ab Titer,a Mean ± SD | |||
| DENV-specific IgG | 373 (99.2) | 4.82 ± 0.61 | 372 (98.9) | 4.99 ± 0.63 | 103.8 | <.05 |
| DENV immunity | ||||||
| DENV-1 | 17 (4.5) | 1.47 ± 0.24 | 22 (5.8) | 1.48 ± 0.16 | 103.6 | .53 |
| DENV-2 | 10 (2.6) | 1.51 ± 0.31 | 9 (2.4) | 1.37 ± 0.10 | 92.7 | .23 |
| DENV-3 | 333 (88.5) | 2.47 ± 0.66 | 340 (90.4) | 2.63 ± 0.69 | 108.2 | <.05 |
| DENV-4 | 127 (33.7) | 1.56 ± 0.44 | 151 (40.1) | 1.70 ± 0.46 | 110.3 | <.05 |
| DENV-specific IgG subclass | ||||||
| IgG1 | 353 (94.6) | 4.31 ± 0.64 | 354 (95.6) | 4.40 ± 0.64 | 103.3 | <.05 |
| IgG4 | 241 (64.2) | 2.56 ± 0.51 | 213 (56.9) | 2.53 ± 0.53 | 97.0 | <.05 |
Abbreviation: SD, standard deviation.
a Log transformed (log10).
b Calculated as follows: [newborn antibody titer/maternal antibody titer] x 100.
c Wilcoxon test (paired samples).